Occasional sleeplessness in children is common and often challenging to manage. It has a significant impact on quality of life in children and their families.1 Ask about your patients’ sleep routines, and recommend these healthy sleep habits.
Recent short- and long-term safety evaluations have demonstrated melatonin’s favorable safety profile for children. Multiple studies have also shown that melatonin improves sleep onset latency and sleep duration among children and adults.1
Exogenous melatonin does not diminish the body’s ability to produce melatonin naturally.2 With a half-life of 35 to 50 minutes, exogenous melatonin reaches peak plasma concentrations after 60 minutes of administration, and 90% of it is cleared in a single passage through the liver.3,4 A small amount is excreted in urine, and a small amount is found in saliva.4
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
REFERENCES: 1. Goldman RD, Bongiorno PB, Olcese JM, Witt-Enderby PA, Shatkin JP. Myths and evidence regarding melatonin supplementation for occasional sleeplessness in the pediatric population. Pediatr Ann. 2021;50(9):e391-e395. 2. Wright J, Aldhous M, Franey C, English J, Arendt J. The effects of exogenous melatonin on endocrine function in man. Clin Endocrinol (Oxf). 1986;24(4):375-382. 3. Melatonin. DrugBank. Accessed July 7, 2021. https://go.drugbank.com/drugs/DB010654. Tordjman S, Chokron S, Delorme R, et al. Melatonin: pharmacology, functions and therapeutic benefits. Curr Neuropharmacol. 2017;15(3):434-443.
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